IS IT TRUE MAY 21, 2018

first_imgWe hope that today’s “Readers Forum” will provoke honest and open dialogue concerning issues that we, as responsible citizens of this community, need to address in a rational and responsible way?IS IT TRUE that yesterday a member of the CCO staff talked with a potential candidate considering running for the Vanderburgh County Prosecutor on the Democratic ticket in the upcoming General election?  …if this individual decides to run for this office it looks like the current Vanderburgh County Prosecutor will be involved in the biggest political battle of his career?  …please don’t ask us to divulge his name because we pledged not to do it? IS IT TRUE we been informed that that lifelong Democrat Steve Melcher recently bolted and announced that he is now a Republican must now depend on future campaign contributions to come from non-union sources?  …were told that when Melcher ran as a Democrat around 90% of his political contributions came from local union members? IS IT TRUE that the cost of compliance is estimated at $560 per pound and the retail tax of 35% make the cost to break even calculate to $95 per ounce?…the street price of cannabis is already below $100 per ounce so that means that a legal operation can not compete with illegal sellers which guarantees a permanent black market?…the State of California has done something that is difficult and thought to be impossible and that is the fact that they have made it impossible to make a profit by selling weed?…of course all of the government officials are aghast at the collapse of pricing and the obvious fact that cannabis will not be the goose that lays golden eggs?…they sure sold it to voters like a sure fire ticket to become the golden state again?IS IT TRUE the underperformance of cannabis as a tax generator after a hype campaign to rival the Weinzapfel Administration’s outrageous claims that a downtown hockey rink would not only pay for itself but would also bring in an unsubsidized hotel?…the reality is that while cannabis is not going to make every Californian rich, it is positive cash flow unlike Weinzapfel’s folly on Main Street that costs the taxpayers of Evansville $9 million per year?…what really seems impossible is expecting politicians who want something to tell the truth about the outcomes?…it is mind boggling to reflect on how far short the Ford Center’s financial performance has been when compared to the sales job that the hand picked consultants projected?…it would have at least been a plus to legalize weed and keep Roberts Stadium in place? FacebookTwitterCopy LinkEmailShare Todays READERS POLL question is: Do you feel its time for the taxpayers of this community to start holding our public officials accountable for their bad business decisions concerning tax increases? IS IT TRUE we are wondering why our City officials are being extremely quiet concerning the details of the proposed 2019 city budget? …we are told that the deficit spending habits of our city officials have finally caught up with them?IS IT TRUE we still stand behind our predictions that in order to fund the City Of Evansville 2019 budget request either the City Council or the Mayor will have to make serious budget cuts?IS IT TRUE it seems as though that a couple of the powers that be are bound and determined to drive people out of Vanderburgh County?…with the water and sewer bills projected to rocket into the $250 per month range when the EPA mandate is satisfied, projected property tax increases over the next several years, another reduction of the Homestead tax credit for 2019 may be planned, and an increase in the local income tax in 2018 things are looking dim for the average taxpayer beginning in 2019?IS IT TRUE we wonder if the Evansville Water and Sewer Utilities Department are still providing the owners of the McCurdy with water and sewer services even though they owe the City around a $1 1/2 million dollars for past water and sewer bills?  …if we owed a water and sewer bill for over six (6) months our water would have long been shut off? IS IT TRUE the best way for Evansville City Council to balance the 2019 budget is to make budget cuts not increase taxes? IS IT TRUE that last year out of town developers announced that they were planning to renovate the former Old National Bank tower at 420 Main Street in downtown Evansville ran into a snag in getting the project financed?…the 18 story building has been sparsely occupied and on a starvation level of maintenance since ONB moved out of the building years ago? …we wonder why the proposed developers are having problems with financing the renovatio9ns effort of this building because the sale price is extremely affordable?IS IT TRUE  that last year the CVB committed a whopping $300,000 request ($100,000 per year for three year period) to help fund the “E Is For Everyone” campaign?  …we wonder how that investment has turned out so far?IS IT TRUE we are pleased that at least a couple of City of Evansville Council members finally realizes that the city doesn’t have a revenue problem but they do have a spending problemIS IT TRUE that the excise tax revenue collected by the State of California on recreational cannabis during the first quarter of 2018 was just released yesterday?…excise tax is not collected on medicinal cannabis so this tax is a real indicator of the expectations for recreational use?…the number is $34 million which may sound like a lot of money but when one considers that there are 40 million Californians, the reality sets in that the state collected less than one penny per day for each resident?…it is mind boggling to think that there was such delusion about the money that would come in that some officials were counting on recreational cannabis taxes to solve pension problems, finance education reform and even buy Hummers for law enforcement officers?…the cost of the regulatory agency to oversee recreational cannabis already costs nearly $5 million per quarter so there is a distinct possibility that the state will lose money on this little venture? Please take time and read our articles entitled “STATEHOUSE Files, CHANNEL 44 NEWS, LAW ENFORCEMENT, READERS POLL, BIRTHDAYS, HOT JOBS” and “LOCAL SPORTS”.You now are able to subscribe to get the CCO daily.If you would like to advertise on the CCO please contact us [email protected] IS IT TRUE that the CPA firm of London Witte advised the Winnecke Administration to implement a “budget spending plan” more than three years ago?  …as of today that no “budget spending plan” has been developed by the administration as of this date? …we wonder why not one member of City Council confronted the Mayor about this issue?last_img read more

Using body heat to speed healing

first_img Drawing inspiration from plants, animals to restore skin tissue “The AAD bonded to pig skin with over 10 times the adhesive force of a Band-Aid and prevented bacteria from growing, so this technology is already significantly better than most commonly used wound protection products, even before considering its wound-closing properties,” said Benjamin Freedman, a Graduate School of Arts and Sciences’ postdoctoral fellow in the Mooney lab who is leading the project.To test how well their AAD closed wounds, the researchers tested it on patches of mouse skin and found that it reduced the size of the wound area by about 45 percent compared to almost no change in area in the untreated samples, and closed wounds faster than treatments including microgels, chitosan, gelatin, and other types of hydrogels. The AAD also did not cause inflammation or immune responses, indicating that it is safe for use in and on living tissues.Furthermore, the researchers were able to adjust the amount of wound closure performed by the AAD by adding different amounts of acrylamide monomers during the manufacturing process. “This property could be useful when applying the adhesive to wounds on a joint like the elbow, which moves around a lot and would probably benefit from a looser bond, compared to a more static area of the body like the shin,” said co-first author Jianyu Li, a former postdoctoral fellow at the Wyss Institute who is now an assistant professor at McGill University.The team also created a computer simulation of AAD-assisted wound closure, which predicted that AAD could cause human skin to contract at a rate comparable to that of mouse skin, indicating that it has a higher likelihood of displaying a clinical benefit in human patients.“We are continuing this research with studies to learn more about how the mechanical cues exerted by AAD impact the biological process of wound healing, and how AAD performs across a range of different temperatures, as body temperature can vary at different locations,” said Freedman. “We hope to pursue additional preclinical studies to demonstrate AAD’s potential as a medical product, and then work toward commercialization.” A hydrogel that helps stop uncontrolled bleeding Nanofiber dressings heal wounds, promote regeneration Relatedcenter_img Cuts, scrapes, blisters, burns, splinters, and punctures — there are a number of ways our skin can be broken. Most treatments for skin wounds involve simply covering them with a barrier (usually an adhesive gauze bandage) to keep them moist, limit pain, and reduce exposure to infectious microbes, but they do not actively assist in the healing process.More sophisticated wound dressings that can monitor aspects of healing such as pH and temperature and deliver therapies to a wound site have been developed in recent years, but they are complex to manufacture, expensive, and difficult to customize, limiting their potential for widespread use.Now, a new, scalable approach to speeding up wound healing has been developed based on heat-responsive hydrogels that are mechanically active, stretchy, tough, highly adhesive, and antimicrobial: active adhesive dressings (AADs). Created by researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University, the Harvard John A. Paulson School for Engineering and Applied Sciences (SEAS), and McGill University, AADs can close wounds significantly faster than other methods and prevent bacterial growth without the need for any additional apparatus or stimuli. The research is reported in Science Advances.“This technology has the potential to be used not only for skin injuries, but also for chronic wounds like diabetic ulcers and pressure sores, for drug delivery, and as components of soft robotics-based therapies,” said corresponding author David Mooney, a founding core faculty member of the Wyss Institute and the Robert P. Pinkas Family Professor of Bioengineering at SEAS.AADs take their inspiration from developing embryos, whose skin is able to heal itself completely, without forming scar tissue. To achieve this, the embryonic skin cells around a wound produce fibers made of the protein actin that contract to draw the wound edges together, like a drawstring bag being pulled closed. Skin cells lose this ability once a fetus develops past a certain age, and any injuries that occur after that point cause inflammation and scarring during the healing process.To mimic the contractile forces that pull embryonic skin wounds closed, the researchers extended the design of previously developed tough, adhesive hydrogels by adding a thermoresponsive polymer known as PNIPAm, which both repels water and shrinks at around 90 degrees Fahrenheit. The resulting hybrid hydrogel begins to contract when exposed to body heat, and transmits the force of the contracting PNIPAm component to the underlying tissue viastrong bonds between the alginate hydrogel and the tissue. In addition, silver nanoparticles are embedded in the AAD to provide antimicrobial protection. “This technology has the potential to be used not only for skin injuries, but also for chronic wounds like diabetic ulcers and pressure sores, for drug delivery, and as components of soft robotics-based therapies.” — David Mooney Works in patients on blood thinners or with bleeding disorders Additional authors of the paper include co-first author Serena Blacklow, a former member of the Mooney lab who is now a graduate student at the University of California, San Francisco; Mahdi Zeidi, a graduate student at University of Toronto; and Chao Chen, a former graduate student in SEAS who is now a postdoc at UMass Amherst.This research was supported by the National Institutes of Health, The Wyss Institute for Biologically Inspired Engineering at Harvard University, the National Sciences and Engineering Research Council of Canada, the Canada Foundation for Innovation, and the Harvard University Materials Research Science and Engineering Center.last_img read more