Using body heat to speed healing

first_img Drawing inspiration from plants, animals to restore skin tissue “The AAD bonded to pig skin with over 10 times the adhesive force of a Band-Aid and prevented bacteria from growing, so this technology is already significantly better than most commonly used wound protection products, even before considering its wound-closing properties,” said Benjamin Freedman, a Graduate School of Arts and Sciences’ postdoctoral fellow in the Mooney lab who is leading the project.To test how well their AAD closed wounds, the researchers tested it on patches of mouse skin and found that it reduced the size of the wound area by about 45 percent compared to almost no change in area in the untreated samples, and closed wounds faster than treatments including microgels, chitosan, gelatin, and other types of hydrogels. The AAD also did not cause inflammation or immune responses, indicating that it is safe for use in and on living tissues.Furthermore, the researchers were able to adjust the amount of wound closure performed by the AAD by adding different amounts of acrylamide monomers during the manufacturing process. “This property could be useful when applying the adhesive to wounds on a joint like the elbow, which moves around a lot and would probably benefit from a looser bond, compared to a more static area of the body like the shin,” said co-first author Jianyu Li, a former postdoctoral fellow at the Wyss Institute who is now an assistant professor at McGill University.The team also created a computer simulation of AAD-assisted wound closure, which predicted that AAD could cause human skin to contract at a rate comparable to that of mouse skin, indicating that it has a higher likelihood of displaying a clinical benefit in human patients.“We are continuing this research with studies to learn more about how the mechanical cues exerted by AAD impact the biological process of wound healing, and how AAD performs across a range of different temperatures, as body temperature can vary at different locations,” said Freedman. “We hope to pursue additional preclinical studies to demonstrate AAD’s potential as a medical product, and then work toward commercialization.” A hydrogel that helps stop uncontrolled bleeding Nanofiber dressings heal wounds, promote regeneration Relatedcenter_img Cuts, scrapes, blisters, burns, splinters, and punctures — there are a number of ways our skin can be broken. Most treatments for skin wounds involve simply covering them with a barrier (usually an adhesive gauze bandage) to keep them moist, limit pain, and reduce exposure to infectious microbes, but they do not actively assist in the healing process.More sophisticated wound dressings that can monitor aspects of healing such as pH and temperature and deliver therapies to a wound site have been developed in recent years, but they are complex to manufacture, expensive, and difficult to customize, limiting their potential for widespread use.Now, a new, scalable approach to speeding up wound healing has been developed based on heat-responsive hydrogels that are mechanically active, stretchy, tough, highly adhesive, and antimicrobial: active adhesive dressings (AADs). Created by researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University, the Harvard John A. Paulson School for Engineering and Applied Sciences (SEAS), and McGill University, AADs can close wounds significantly faster than other methods and prevent bacterial growth without the need for any additional apparatus or stimuli. The research is reported in Science Advances.“This technology has the potential to be used not only for skin injuries, but also for chronic wounds like diabetic ulcers and pressure sores, for drug delivery, and as components of soft robotics-based therapies,” said corresponding author David Mooney, a founding core faculty member of the Wyss Institute and the Robert P. Pinkas Family Professor of Bioengineering at SEAS.AADs take their inspiration from developing embryos, whose skin is able to heal itself completely, without forming scar tissue. To achieve this, the embryonic skin cells around a wound produce fibers made of the protein actin that contract to draw the wound edges together, like a drawstring bag being pulled closed. Skin cells lose this ability once a fetus develops past a certain age, and any injuries that occur after that point cause inflammation and scarring during the healing process.To mimic the contractile forces that pull embryonic skin wounds closed, the researchers extended the design of previously developed tough, adhesive hydrogels by adding a thermoresponsive polymer known as PNIPAm, which both repels water and shrinks at around 90 degrees Fahrenheit. The resulting hybrid hydrogel begins to contract when exposed to body heat, and transmits the force of the contracting PNIPAm component to the underlying tissue viastrong bonds between the alginate hydrogel and the tissue. In addition, silver nanoparticles are embedded in the AAD to provide antimicrobial protection. “This technology has the potential to be used not only for skin injuries, but also for chronic wounds like diabetic ulcers and pressure sores, for drug delivery, and as components of soft robotics-based therapies.” — David Mooney Works in patients on blood thinners or with bleeding disorders Additional authors of the paper include co-first author Serena Blacklow, a former member of the Mooney lab who is now a graduate student at the University of California, San Francisco; Mahdi Zeidi, a graduate student at University of Toronto; and Chao Chen, a former graduate student in SEAS who is now a postdoc at UMass Amherst.This research was supported by the National Institutes of Health, The Wyss Institute for Biologically Inspired Engineering at Harvard University, the National Sciences and Engineering Research Council of Canada, the Canada Foundation for Innovation, and the Harvard University Materials Research Science and Engineering Center.last_img read more

ESB Networks warning to farmers transporting hay and straw

first_imgESB Networks has issued a public safety warning to the Donegal farming community about transporting high loads of hay and straw which may come in contact with overhead electricity wires.Coming in contact with overhead electricity wires is extremely dangerous and can be fatal.Electricity wires are erected at best international heights that permit the transit of loads safely. However serious problems arise when loads are too high and interfere with live overhead electricity wires.ESB Networks Safety Manager Arthur Byrne says: “At this busy time for farmers, hay and straw is being saved and transported on roads around the country. ESB Networks is concerned about a number of incidents where tractors pulling high loads of hay and straw, have come in contact with the overhead electricity network.“In one case, where a high load pulled down live electricity wires, both the tractor and load caught fire. Thankfully the driver escaped injury, but it serves as a timely warning to the farming community on these hazards.”When loading hay and straw onto a tractor or lorry, our advice is to always ensure that the load is low enough to allow for safe transit, and avoid putting the public at risk. When planning the route with a high load, identify where electricity wires cross the road . Where there is doubt, establish if there is adequate clearance and, if necessary contact ESB Networks. NEVER, under any circumstances touch an electricity wire or anything the wire may be in contact with, including the inside or outside of a tractor/lorry/trailer etc. Please contact ESB Networks immediately on 1850 372 999.Please read carefully the “Farm Safely with Electricity” Booklet which can be downloaded from our website www.esbnetworks.ie. Also the “Guidelines for safe working near overhead lines in agriculture” and the “Code of Practice for Avoiding danger from overhead electricity lines”. These can be downloaded from the HSA (www.hsa/ie ) and ESB Networks websites (www.esbnetworks.ie)ESB Networks warning to farmers transporting hay and straw was last modified: August 3rd, 2018 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:ESBfarmersoverhead wireslast_img read more